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Notably, the activity of the primary sensor of cellular stress, nuclear factor (erythroid-derived 2)-like 2 (Nrf2), is diminished with ageing 31,32 and in MS 33

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Cis-aconityl group Cis -aconityl group, an amide derivative of maleic acid, has also been employed as an acid-cleavable linkage for designing pH-responsive polymer-drug conjugates and drug carriers